3-thiophenecarboxylic acid phenyl ester

Base Information

• Chemical Name: 3-thiophenecarboxylic acid phenyl ester
• CAS No.: 14596-83-9
• Molecular Formula: C₁₁H₈O₂S
• Molecular Weight: 204.249
• Mol file: 14596-83-9.mol

Synonyms:3-thiophenecarboxylic acid phenyl ester

Chemical Property of 3-thiophenecarboxylic acid phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-thiophenecarboxylic acid phenyl ester

There total 10 articles about 3-thiophenecarboxylic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-thienyl iodide (10486-61-0) + phenyl formate (1864-94-4) → 3-thiophenecarboxylic acid phenyl ester (14596-83-9)

Guidance literature:

With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In acetonitrile; at 20 ℃; for 6h;

DOI:10.1002/adsc.201700751

Reference yield: 95.0%

3-Bromothiophene (872-31-1) + phenyl formate (1864-94-4) → 3-thiophenecarboxylic acid phenyl ester (14596-83-9)

Guidance literature:

With palladium diacetate; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In acetonitrile; at 80 ℃; Inert atmosphere;

DOI:10.1021/ol301192s

Reference yield: 89.0%

3-Bromothiophene (872-31-1) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) + phenol (108-95-2,27073-41-2) → 3-thiophenecarboxylic acid phenyl ester (14596-83-9)

Guidance literature:

With tributyl-amine; In diethylene glycol dimethyl ether; at 150 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0030-1260060

upstream raw materials:

bis(3-thiophenecarbonyl) peroxide

3-Bromothiophene

molybdenum hexacarbonyl

phenol

Downstream raw materials:

tri-n-butyl(thien-3-yl)tin

3-(3-(4-methoxyphenyl)propyl)thiophene

3-thiophenecarbonitrile

Refernces

• 1、 -. "Method of coupling, and the coupling method using the aromatic group-substituted heterocyclic compound". Paragraph 0202-0207. . Retrieved 2020/09/17.
• 2、 Dohi, Toshifumi,Koseki, Daichi,Sumida, Kohei,Okada, Kana,Mizuno, Serina,Kato, Asami,Morimoto, Koji,Kita, Yasuyuki. "Metal-Free O-Arylation of Carboxylic Acid by Active Diaryliodonium(III) Intermediates Generated in situ from Iodosoarenes". . p. 3503 - 3508. Retrieved 2017/09/13.