6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

Base Information

Chemical Name:6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one
CAS No.:817166-76-0
Molecular Formula:C₂₅H₃₇ClO₅Si
Molecular Weight:481.104
Hs Code.:

Synonyms:6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

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Chemical Property of 6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

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Technology Process of 6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

There total 7 articles about 6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 817166-54-4
3-chloro-4-methoxy-2-triisopropylsilanyloxymethyl-benzaldehyde

: 817166-31-7
(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester

: 817166-76-0
6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

Guidance literature:: (2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 0.166667h;

3-chloro-4-methoxy-2-triisopropylsilanyloxymethyl-benzaldehyde; In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1021/ol048075l

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 817166-76-0
6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / imidazole / dimethylformamide / 3 h / 23 °C

2.1: tert-butyllithium / tetrahydrofuran; pentane / 0.5 h / -96 °C

2.2: 90 percent / tetrahydrofuran; pentane / 1.17 h / -96 - 23 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.17 h / 0 °C

3.2: 74 percent / tetrahydrofuran / -78 - 0 °C

With 1H-imidazole; tert.-butyl lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide; pentane;
DOI:10.1021/ol048075l

Reference yield:

: 6971-51-3
3-methoxybenzyl alcohol

: 817166-76-0
6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / toluene; hexane / 1 h / 23 °C

1.2: 66 percent / hexachloroethane / toluene; hexane / 0.17 h / 23 °C

2.1: 92 percent / N-bromosuccinimide / dimethylformamide / 56 h / 23 °C

3.1: 96 percent / imidazole / dimethylformamide / 3 h / 23 °C

4.1: tert-butyllithium / tetrahydrofuran; pentane / 0.5 h / -96 °C

4.2: 90 percent / tetrahydrofuran; pentane / 1.17 h / -96 - 23 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.17 h / 0 °C

5.2: 74 percent / tetrahydrofuran / -78 - 0 °C

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; tert.-butyl lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene; pentane;
DOI:10.1021/ol048075l