(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester

Base Information

• Chemical Name: (2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester
• CAS No.: 817166-31-7
• Molecular Formula: C₁₉H₁₉O₆P
• Molecular Weight: 374.33
• Mol file: 817166-31-7.mol

Synonyms:(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester

Chemical Property of (2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester

There total 1 articles about (2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

diphenyl hydrogen phosphite (4712-55-4) + 6-(chloromethyl)-2,2-dimethyl(4H)-1,3-dioxin-4-one (81956-31-2) → (2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester (817166-31-7)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 - 23 ℃; for 10h;

DOI:10.1021/ol048075l

Reference yield: 97.0%

ortho-bromobenzaldehyde (6630-33-7) + (2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester (817166-31-7) → 6-[(Z)-2-(2-Bromo-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

Guidance literature:

(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 0.333333h;

ortho-bromobenzaldehyde; In tetrahydrofuran; at 0 ℃; for 18h;

DOI:10.1021/ol048075l

Reference yield: 90.0%

3-[(triisopropylsilyl)oxy]benzaldehyde (817166-73-7) + (2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester (817166-31-7) → 2,2-Dimethyl-6-[(Z)-2-(3-triisopropylsilanyloxy-phenyl)-vinyl]-[1,3]dioxin-4-one

Guidance literature:

(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-ylmethyl)-phosphonic acid diphenyl ester; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 23 ℃; for 0.333333h;

3-[(triisopropylsilyl)oxy]benzaldehyde; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/ol048075l

upstream raw materials:

diphenyl hydrogen phosphite

6-(chloromethyl)-2,2-dimethyl(4H)-1,3-dioxin-4-one

Downstream raw materials:

6-[(Z)-2-(2,4-Dimethoxy-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one

2,2-Dimethyl-6-[(Z)-2-(2-nitro-phenyl)-vinyl]-[1,3]dioxin-4-one

6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one