N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine

Base Information

Chemical Name:N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine
CAS No.:705254-53-1
Molecular Formula:C₂₀H₂₃N₅O₃
Molecular Weight:381.434
Hs Code.:

Synonyms:N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine

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Chemical Property of N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine

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Technology Process of N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine

There total 6 articles about N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 705254-52-0
N-6-(4-tert-butylbenzoyl)-9-[3-benzyloxy-2-(benzyloxymethyl)prop-1-enyl]adenine

: 9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine

: 705254-53-1
N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine

Guidance literature:: With boron trichloride; In dichloromethane; at -78 ℃; for 4h;
DOI:10.1039/b316304k

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 705254-53-1
N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 60 percent / dimethylformamide / 72 h / 110 °C

2.1: pyridine / 2 h / 20 °C

2.2: 73 percent / pyridine; aq. NaOH / methanol / 0.5 h / 20 °C

3.1: pyridine / 2 h / 20 °C

4.1: 3.15 g / S₈ / 2 h

5.1: 95 percent / NaH; t-amyl alcohol / toluene / 72 h / 20 °C

6.1: 20 percent / BCl₃ / CH₂Cl₂ / 4 h / -78 °C

With pyridine; sulfur; tert-Amyl alcohol; boron trichloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b316304k

Reference yield:

: 705254-49-5
9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]adenine

: 705254-53-1
N-6-(4-tert-butylbenzoyl)-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]adenine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 2 h / 20 °C

1.2: 73 percent / pyridine; aq. NaOH / methanol / 0.5 h / 20 °C

2.1: pyridine / 2 h / 20 °C

3.1: 3.15 g / S₈ / 2 h

4.1: 95 percent / NaH; t-amyl alcohol / toluene / 72 h / 20 °C

5.1: 20 percent / BCl₃ / CH₂Cl₂ / 4 h / -78 °C

With pyridine; sulfur; tert-Amyl alcohol; boron trichloride; sodium hydride; In dichloromethane; toluene;
DOI:10.1039/b316304k