N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

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Chemical Name:N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide
CAS No.:1195781-47-5
Molecular Formula:C₁₆H₁₃FN₄O₂S
Molecular Weight:344.369
Hs Code.:

Synonyms:N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

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Chemical Property of N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

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Technology Process of N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

There total 6 articles about N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1195778-95-0
tert-butyl [4-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-3-fluorophenyl]carbamate

: 1195781-47-5
N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: tert-butyl [4-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-3-fluorophenyl]carbamate; With trifluoroacetic acid; In methoxybenzene; at 0 ℃; for 2h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 859537-27-2
N-(3-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

: 1195781-47-5
N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / dimethyl sulfoxide / 4 h / 20 °C

2: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 20 °C

3: bromine / acetic acid / 0 - 20 °C

4: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C

5: trifluoroacetic acid / methoxybenzene / 2 h / 0 °C

With hydrogen; bromine; caesium carbonate; triethylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In methanol; ISOPROPYLAMIDE; acetic acid; dimethyl sulfoxide; methoxybenzene;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1195781-47-5
N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / dimethyl sulfoxide / 4 h / 20 °C

2: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 20 °C

3: bromine / acetic acid / 0 - 20 °C

4: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C

5: trifluoroacetic acid / methoxybenzene / 2 h / 0 °C

With hydrogen; bromine; caesium carbonate; triethylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In methanol; ISOPROPYLAMIDE; acetic acid; dimethyl sulfoxide; methoxybenzene;