3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1315245-43-2
• Molecular Formula: C₁₅H₁₇ClN₂O₃S
• Molecular Weight: 340.831
• Mol file: 1315245-43-2.mol

Synonyms:3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester

Chemical Property of 3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine → 3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester (1315245-43-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2011.04.050

Reference yield:

4-chloro-aniline (106-47-8) → 3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester (1315245-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 1 h / 0 - 20 °C

2.1: triethylamine / 1,4-dioxane; water / 0.5 h / 0 °C

2.2: 2 h / pH 2

3.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C

With dmap; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.ejmech.2011.04.050

Reference yield: 47.0%

3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester (1315245-43-2) + 4-chlorobenzaldehyde (104-88-1) → 3-(4-chlorophenyl)-5-[(4-chlorophenyl) hydroxy methyl]-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester

Guidance literature:

3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

4-chlorobenzaldehyde; In tetrahydrofuran; for 0.5h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.050

upstream raw materials:

di-tert-butyl dicarbonate

4-chloro-aniline

Downstream raw materials:

(R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate

(R)-[(S)-(4-chlorophenyl)((R)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate