(R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate

Base Information

• Chemical Name: (R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate
• CAS No.: 1315245-87-4
• Molecular Formula: C₂₆H₂₂Cl₂N₂O₄S
• Molecular Weight: 529.444
• Mol file: 1315245-87-4.mol

Synonyms:(R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate

Chemical Property of (R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate

There total 6 articles about (R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-chlorophenyl)-5-[(4-chlorophenyl)hydroxymethyl]-5-methyl-4-oxo-2-thioxoimidazolidine + (R)-methoxyphenylacetic acid (3966-32-3) → (R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate (1315245-87-4) + (R)-[(S)-(4-chlorophenyl)((R)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate (1315245-88-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2011.04.050

Reference yield:

4-chloro-aniline (106-47-8) → (R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate (1315245-87-4) + (R)-[(S)-(4-chlorophenyl)((R)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate (1315245-88-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 1 h / 0 - 20 °C

2.1: triethylamine / 1,4-dioxane; water / 0.5 h / 0 °C

2.2: 2 h / pH 2

3.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

4.2: 0.5 h / Inert atmosphere

4.3: Inert atmosphere

5.1: hydrogenchloride / methanol; dichloromethane / 12 h

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With hydrogenchloride; dmap; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2011.04.050

Reference yield:

4-Chlorophenyl isothiocyanate (2131-55-7) → (R)-[(R)-(4-chlorophenyl)((S)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate (1315245-87-4) + (R)-[(S)-(4-chlorophenyl)((R)-1-(4-chlorophenyl)-4-methyl-5-oxo-2-thioxoimidazolidin-4-yl)methyl] 2-methoxy-2-phenylacetate (1315245-88-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / 1,4-dioxane; water / 0.5 h / 0 °C

1.2: 2 h / pH 2

2.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

3.3: Inert atmosphere

4.1: hydrogenchloride / methanol; dichloromethane / 12 h

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2011.04.050

upstream raw materials:

3-(4-chlorophenyl)-5-methyl-4-oxo-2-thioxoimidazolidine-1-carboxylic acid tert-butyl ester

(R)-methoxyphenylacetic acid

4-chloro-aniline

4-Chlorophenyl isothiocyanate