N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide

Base Information

• Chemical Name: N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide
• CAS No.: 1376642-10-2
• Molecular Formula: C₁₈H₁₅ClN₄O
• Molecular Weight: 338.796
• Mol file: 1376642-10-2.mol

Synonyms:N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide

Chemical Property of N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide

There total 6 articles about N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

6-chloro-2-methyl-N4-phenylpyrimidine-4,5-diamine (129006-34-4) + benzoyl chloride (98-88-4) → N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide (1376642-10-2)

Guidance literature:

With dmap; In tetrahydrofuran; at 67 ℃; for 12h;

DOI:10.1002/cbdv.201800493

Reference yield:

5-amino-4,6-dichloro-2-methylpyrimidine (39906-04-2) → N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide (1376642-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 16 h / 20 °C / Reflux

2: pyridine / dichloromethane / 3 h / 0 - 20 °C

With pyridine; hydrogenchloride; In ethanol; dichloromethane; water;

DOI:10.1016/j.tet.2012.03.080

Reference yield:

2-methyl-4,6-dihydroxypyrimidine (1194-22-5) → N-(4-chloro-2-methyl-6-(phenylamino)pyrimidin-5-yl)benzamide (1376642-10-2)

Guidance literature:

Multi-step reaction with 5 steps

1: nitric acid; acetic acid / 2 h / 0 °C

2: trichlorophosphate; N,N-diethylaniline / 3 h / 115 °C

3: iron; hydrogenchloride / methanol; water / 5 h / 75 °C

4: hydrogenchloride / ethanol; water / 24 h / 82 °C

5: dmap / tetrahydrofuran / 12 h / 67 °C

With hydrogenchloride; dmap; nitric acid; iron; acetic acid; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1002/cbdv.201800493

upstream raw materials:

5-amino-4,6-dichloro-2-methylpyrimidine

6-chloro-2-methyl-N₄-phenylpyrimidine-4,5-diamine

benzoyl chloride

aniline