ethyl 1-[4-(5-fluoro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate

Base Information

• Chemical Name: ethyl 1-[4-(5-fluoro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate
• CAS No.: 1207618-58-3
• Molecular Formula: C₁₇H₁₉FN₂O₃S
• Molecular Weight: 350.414
• Mol file: 1207618-58-3.mol

Synonyms:ethyl 1-[4-(5-fluoro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate

Chemical Property of ethyl 1-[4-(5-fluoro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 1-[4-(5-fluoro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate

There total 2 articles about ethyl 1-[4-(5-fluoro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-thiocarbamoyl-piperidine-4-carboxylic acid ethyl ester (675149-01-6) + α-bromo-(2-hydroxy-5-fluoro)acetophenone (126581-65-5) → ethyl 1-[4-(5-fluoro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate (1207618-58-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

→ ethyl 1-[4-(5-fluoro-2-hydroxyphenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate (1207618-58-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; at 80 ℃; for 16h; Inert atmosphere;

upstream raw materials:

1-thiocarbamoyl-piperidine-4-carboxylic acid ethyl ester

α-bromo-(2-hydroxy-5-fluoro)acetophenone