tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate

Base Information

• Chemical Name: tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate
• CAS No.: 149298-54-4
• Molecular Formula: C₂₂H₂₉N₃O₅
• Molecular Weight: 415.489
• Mol file: 149298-54-4.mol

Synonyms:tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate

Chemical Property of tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate

There total 3 articles about tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

N-<3-(benzyloxycarbonyl)amino-3-tert-butoxycarbonylpropyl>urea (149298-53-3) + acetylacetone (123-54-6,81235-32-7) → tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate (149298-54-4)

Guidance literature:

With hydrogenchloride; In tert-butyl alcohol; at 70 ℃; for 12h;

DOI:10.1248/cpb.42.1514

Reference yield:

benzyloxycarbonyl-L-glutamic acid α-tert-butyl ester γ-hydrazide (95022-60-9) → tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate (149298-54-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 M HCl, NaNO₂ / CHCl₃; H₂O / 0.5 h

2: NH₃ (gas) / CHCl₃ / 3 h / Ambient temperature

3: 47 percent / HCl / 2-methyl-propan-2-ol / 12 h / 70 °C

With hydrogenchloride; ammonia; sodium nitrite; In chloroform; water; tert-butyl alcohol;

DOI:10.1248/cpb.42.1514

Reference yield:

(S)-2-Benzyloxycarbonylamino-4-isocyanato-butyric acid tert-butyl ester (1026811-50-6) → tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate (149298-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ (gas) / CHCl₃ / 3 h / Ambient temperature

2: 47 percent / HCl / 2-methyl-propan-2-ol / 12 h / 70 °C

With hydrogenchloride; ammonia; In chloroform; tert-butyl alcohol;

DOI:10.1248/cpb.42.1514

upstream raw materials:

N-<3-(benzyloxycarbonyl)amino-3-tert-butoxycarbonylpropyl>urea

acetylacetone

benzyloxycarbonyl-L-glutamic acid α-tert-butyl ester γ-hydrazide

(S)-2-Benzyloxycarbonylamino-4-isocyanato-butyric acid tert-butyl ester

Downstream raw materials:

2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyric acid