2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester

Base Information

• Chemical Name: 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester
• CAS No.: 1303530-10-0
• Molecular Formula: C₁₈H₂₀BrNO₄S
• Molecular Weight: 426.331
• Mol file: 1303530-10-0.mol

Synonyms:2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester

Chemical Property of 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester

There total 3 articles about 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(S)-N-tosylalanine methyl ester (59724-69-5) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester (1303530-10-0)

Guidance literature:

(S)-N-tosylalanine methyl ester; With potassium carbonate; In acetonitrile; at 25 ℃; for 0.5h; Sonication;

1-Bromo-2-bromomethyl-benzene; In acetonitrile; at 25 ℃; for 14h; Sonication;

DOI:10.1055/s-0030-1258406

Reference yield:

p-tosyl-L-alanine (4816-81-3,21957-58-4,85471-45-0) → 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester (1303530-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / 20 h / 90 °C

2.1: potassium carbonate / acetonitrile / 0.5 h / 25 °C / Sonication

2.2: 14 h / 25 °C / Sonication

With potassium carbonate; toluene-4-sulfonic acid; In acetonitrile;

DOI:10.1055/s-0030-1258406

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]propionic acid methyl ester (1303530-10-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 25 °C

2.1: toluene-4-sulfonic acid / 20 h / 90 °C

3.1: potassium carbonate / acetonitrile / 0.5 h / 25 °C / Sonication

3.2: 14 h / 25 °C / Sonication

With potassium carbonate; toluene-4-sulfonic acid; sodium hydroxide; In water; acetonitrile;

DOI:10.1055/s-0030-1258406

upstream raw materials:

p-tosyl-L-alanine

p-toluenesulfonyl chloride

(S)-N-tosylalanine methyl ester

1-Bromo-2-bromomethyl-benzene

Downstream raw materials:

(S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

N-(2-bromobenzyl)-N-(2-hydroxy-1-methylethyl)-4-methylbenzenesulfonamide