(S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

Base Information

Chemical Name:(S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine
CAS No.:932725-30-9
Molecular Formula:C₁₇H₁₉NO₃S
Molecular Weight:317.409
Hs Code.:

Synonyms:(S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

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Chemical Property of (S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

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Technology Process of (S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

There total 6 articles about (S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 932725-23-0
(S)-N-(2-hydroxy-benzyl)-N-(2-hydroxy-1-methyl-ethyl)-4-methyl-benzenesulfonamide

: 932725-30-9
(S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.10.126

Reference yield: 69.0%

: 1303530-18-8
N-(2-bromobenzyl)-N-(2-hydroxy-1-methylethyl)-4-methylbenzenesulfonamide

: 932725-30-9
(S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 90 ℃; for 18h; Inert atmosphere;
DOI:10.1055/s-0030-1258406

Reference yield:

: 4816-81-3,21957-58-4,85471-45-0
p-tosyl-L-alanine

: 932725-30-9
(S)-3-methyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / 20 h / 90 °C

2.1: potassium carbonate / acetonitrile / 0.5 h / 25 °C / Sonication

2.2: 14 h / 25 °C / Sonication

3.1: lithium borohydride / tetrahydrofuran / 20 h / 90 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / 90 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium borohydride; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1055/s-0030-1258406