benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Base Information

Chemical Name:benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate
CAS No.:1569905-96-9
Molecular Formula:C₄₇H₄₆N₂O₆
Molecular Weight:734.892
Hs Code.:

Synonyms:benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

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Chemical Property of benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

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Technology Process of benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

There total 12 articles about benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₄₀N₂O₆

: 100-39-0
benzyl bromide

: 1569905-96-9
benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1055/s-0033-1339892

Reference yield:

: 1569905-88-9
tert-butyl N-[3-(10-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl} phenanthren-9-yl)propyl]carbamate

: 1569905-96-9
benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide; lithium hydroxide / water; tetrahydrofuran / 2.5 h / 0 °C

2: hydrogen; palladium 10% on activated carbon / methanol; water / 6 h

3: sodium hydrogencarbonate / water; 1,4-dioxane / 0 - 20 °C

4: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

With palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1339892

Reference yield:

: C₃₀H₃₇NO₅

: 1569905-96-9
benzyl (2R)-3-[10-(3-{[(tert-butoxy)carbonyl]amino}propyl)phenanthren-9-yl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

2.3: -78 - 30 °C / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide / water; tetrahydrofuran / 2.5 h / 0 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol; water / 6 h

5.1: sodium hydrogencarbonate / water; 1,4-dioxane / 0 - 20 °C

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

With n-butyllithium; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydrogencarbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-0033-1339892