6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Base Information

• Chemical Name: 6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester
• CAS No.: 706808-72-2
• Molecular Formula: C₂₀H₂₆N₂O₄
• Molecular Weight: 358.437

Synonyms:6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Chemical Property of 6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Chemical Property:

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Technology Process of 6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

There total 2 articles about 6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C20H26N2O4 (706808-61-9) → 6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (706808-72-2)

Guidance literature:

Grubbs catalyst first generation; In dichloromethane; at 45 ℃; for 8h;

DOI:10.1016/j.tetlet.2004.03.075

Reference yield:

C17H24N2O4 (706808-54-0) → 6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (706808-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH; n-Bu₄NI / dimethylformamide / 25 °C

2: 70 percent / Grubbs' catalyst / CH₂Cl₂ / 8 h / 45 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.03.075

Reference yield: 97.0%

dimethyl acetylenedicarboxylate (762-42-5) + 6-vinyl-4,7-dihydro-3H-[1,2]diazepine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (706808-72-2) → 4,5,5a,8-tetrahydro-1H-benzo[d][1,2]diazepine-2,3,6,7-tetracarboxylic acid 3-benzyl ester 2-tert-butyl ester 6,7-dimethyl ester (706808-75-5)

Guidance literature:

In toluene; at 110 ℃; for 6h;

DOI:10.1016/j.tetlet.2004.03.075

upstream raw materials:

C₂₀H₂₆N₂O₄

C₁₇H₂₄N₂O₄

Downstream raw materials:

4,5,5a,8-tetrahydro-1H-benzo[d][1,2]diazepine-2,3,6,7-tetracarboxylic acid 3-benzyl ester 2-tert-butyl ester 6,7-dimethyl ester

4,5-dihydro-1H-benzo[d][1,2]diazepine-2,3,6,7-tetracarboxylic acid 3-benzyl ester 2-tert-butyl ester 6,7-dimethyl ester

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