1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid

Base Information

Chemical Name:1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid
CAS No.:1295642-66-8
Molecular Formula:C₃₃H₃₈N₂O₅
Molecular Weight:542.675
Hs Code.:

Synonyms:1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid

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Chemical Property of 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid

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Technology Process of 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid

There total 13 articles about 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1643461-53-3
allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate

: 1295642-66-8
1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1039/c4ob00535j

Reference yield: 69.0%

: 1312334-93-2
C₃₇H₄₆N₂O₅

: 1295642-66-8
1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1080/00397911.2013.868490

Reference yield:

: 741606-17-7
1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-5-carboxylic acid tert-butyl ester

: 1295642-66-8
1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 0 - 20 °C

2: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / Reflux

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 16 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; trimethylsilylazide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.085