allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate

Base Information

Chemical Name:allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate
CAS No.:1643461-53-3
Molecular Formula:C₃₆H₄₂N₂O₅
Molecular Weight:582.74
Hs Code.:

Synonyms:allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate

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Chemical Property of allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate

Chemical Property:

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Technology Process of allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate

There total 7 articles about allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1643461-52-2
allyl 1-[2-amino-3-(4-octylphenoxy)propyl]indole-5-carboxylate

: 1885-14-9
phenyl chloroformate

: 1643461-53-3
allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1039/c4ob00535j

Reference yield:

: 1806-26-4
p-Octylphenol

: 1643461-53-3
allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 3 h / 70 °C

2.1: hydrogenchloride / methanol; diethyl ether / 12 h / 20 °C

3.1: triethylamine / methanol; diethyl ether / 12 h / 0 °C

4.1: dmap; triethylamine / dichloromethane / 12 h

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 3 h / 80 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; dmap; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j

Reference yield:

: 1643461-49-7
tert-butyl [1-hydroxy-3-(4-octylphenoxy)propan-2-yl]carbamate

: 1643461-53-3
allyl 1-{3-(4-octylphenoxy)-2-[(phenoxycarbonyl)amino]propyl}indole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 12 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 3 h / 80 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With dmap; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j