(S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

Base Information

Chemical Name:(S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide
CAS No.:1380102-17-9
Molecular Formula:C₁₉H₂₉FN₂O₂
Molecular Weight:336.45
Hs Code.:

Synonyms:(S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

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Chemical Property of (S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

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Technology Process of (S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

There total 4 articles about (S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1380104-48-2
(S)-4-fluoro-N,3-dimethyl-N-(3-methyl-1-oxobutan-2-yl)benzamide

: 1380102-18-0
(R)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

: 1380102-17-9
(S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

Guidance literature:: 4-HYDROXYPIPERIDINE; (S)-4-fluoro-N,3-dimethyl-N-(3-methyl-1-oxobutan-2-yl)benzamide; With acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 3h;

With triethylamine; In ethanol; n-heptane; Resolution of racemate;

Reference yield:

: 455-84-5
4-fluoro-3-methylbonzoyl chloride

: 1380102-18-0
(R)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

: 1380102-17-9
(S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

2.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3.1: acetic acid / dichloromethane / 0.5 h / 20 °C

3.2: 3 h / 20 °C

3.3: Chiralpak AD 5 μιη 20x250 mm column / Resolution of racemate

With Dess-Martin periodane; acetic acid; triethylamine; In dichloromethane;

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1380102-18-0
(R)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

: 1380102-17-9
(S)-4-fluoro-N-(1-(4-hydroxypiperidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.75 h / 55 °C

2.1: triethylamine / dichloromethane / 20 °C / Cooling with ice

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: acetic acid / dichloromethane / 0.5 h / 20 °C

4.2: 3 h / 20 °C

4.3: Chiralpak AD 5 μιη 20x250 mm column / Resolution of racemate

With lithium aluminium tetrahydride; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;