2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Base Information

Chemical Name:2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
CAS No.:1332952-19-8
Molecular Formula:C₂₅H₂₁FN₆O₂
Molecular Weight:456.479
Hs Code.:

Synonyms:2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

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Chemical Property of 2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

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Technology Process of 2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

There total 13 articles about 2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2799-16-8
(2R)-hydroxypropylamine

: 2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid hydrochloride

: 1332952-19-8
2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 153556-42-4
4-bromo-3-fluorobenzoic acid

: 1332952-19-8
2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2.1: potassium carbonate / dichloromethane; water / 2 h / 20 °C

3.1: tetrahydrofuran / 1 h / 0 °C

4.1: water; hydrogen bromide / dimethyl sulfoxide / 60 °C

4.2: 4 h / Reflux

5.1: potassium hydroxide / ethanol; water / Reflux

6.1: hydrogenchloride / ethanol; water / 8 h / 110 °C

7.1: isopropyl alcohol; water / 120 h / 105 °C / Sealed tube

8.1: N,N,N,N,-tetramethylethylenediamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.14 h / 160 °C / Microwave irradiation; Inert atmosphere

9.1: hydrogenchloride; water / 105 °C

10.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; water; hydrogen bromide; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 343564-56-7
4-bromo-3-fluoro-N-methoxy-N-methyl-benzamide

: 1332952-19-8
2-fluoro-N-[(2R)-2-hydroxypropyl]-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 1 h / 0 °C

2.1: water; hydrogen bromide / dimethyl sulfoxide / 60 °C

2.2: 4 h / Reflux

3.1: potassium hydroxide / ethanol; water / Reflux

4.1: hydrogenchloride / ethanol; water / 8 h / 110 °C

5.1: isopropyl alcohol; water / 120 h / 105 °C / Sealed tube

6.1: N,N,N,N,-tetramethylethylenediamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.14 h / 160 °C / Microwave irradiation; Inert atmosphere

7.1: hydrogenchloride; water / 105 °C

8.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; water; hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;