(2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

Base Information

Chemical Name:(2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate
CAS No.:1254709-07-3
Molecular Formula:C₂₈H₃₁Cl₂NO₅
Molecular Weight:532.464
Hs Code.:

Synonyms:(2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

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Chemical Property of (2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

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Technology Process of (2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

There total 1 articles about (2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 15258-73-8
2,6-dichlorobenzyl alcohol

: 1749-08-2
N-(4-methoxy benzylidene)-4-methoxyaniline

: 35059-50-8
t-butyl diazoacetate

: 1254709-07-3
(2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

: (2R,3S)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

: tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

Guidance literature:: With dirhodium tetraacetate; C₃₂H₁₉F₂O₄P; In dichloromethane; at 0 ℃; for 1.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/jo101559p

Reference yield: 84.0%

: 1254709-07-3
(2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

: 1254709-09-5
(2S,3R)-tert-butyl 2-hydroxy-3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)propanoate

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; at 35 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo101559p