N-(4-Methoxybenzylidene)-4-methoxyaniline

Base Information

• Chemical Name: N-(4-Methoxybenzylidene)-4-methoxyaniline
• CAS No.: 1749-08-2
• Molecular Formula: C15H15 N O2
• Molecular Weight: 241.29
• Hs Code.: 2925290090
• European Community (EC) Number: 622-671-4
• NSC Number: 95585
• DSSTox Substance ID: DTXSID30294253
• Nikkaji Number: J1.004.868K
• ChEMBL ID: CHEMBL2064683
• Mol file: 1749-08-2.mol

Synonyms:1749-08-2;N-(4-Methoxybenzylidene)-4-methoxyaniline;N,1-bis(4-methoxyphenyl)methanimine;4-Methoxy-N-(4-methoxybenzylidene)aniline;N-(p-Methoxybenzylidene)-p-anisidine;p-methoxybenzylidene-(4-methoxyphenyl)-amine;Benzenamine, 4-methoxy-N-[(4-methoxyphenyl)methylene]-;NSC95585;Maybridge1_007604;NCIOpen2_006022;SCHEMBL2010515;CHEMBL2064683;SCHEMBL10412841;HMS563B14;DTXSID30294253;ZDOHZYPZEUJYKN-LFIBNONCSA-N;ZDOHZYPZEUJYKN-UHFFFAOYSA-N;BAA74908;NSC-95585;STK089891;AKOS000488759;NS-00005;(1E)-N,1-bis(4-methoxyphenyl)methanimine;(4-methoxybenzylidene)(4-methoxyphenyl)amine;FT-0633821;(E)-4-methoxy-N-(4-methoxybenzylidene)aniline;(E)-N,1-BIS(4-METHOXYPHENYL)METHANIMINE;N-(4-Methoxybenzylidene)-4-methoxyaniline, 97%;A812142;J-011050;4-Methoxy-N-[(E)-(4-methoxyphenyl)methylidene]aniline;BENZENAMINE,4-METHOXY-N-[(4-METHOXYPHENYL)METHYLENE]-;2-Amino-3-bromo-5-nitrobenzonitrile

Chemical Property of N-(4-Methoxybenzylidene)-4-methoxyaniline

Chemical Property:

• Vapor Pressure: 6.38E-06mmHg at 25°C
• Melting Point: 146-150 °C(lit.)
• Boiling Point: 389.5°C at 760 mmHg
• PKA: 4.51±0.50(Predicted)
• Flash Point: 153.2°C
• PSA: 30.82000
• Density: 1.03g/cm³
• LogP: 3.45440
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 241.110278721
• Heavy Atom Count: 18
• Complexity: 251

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,1-Bis(4-methoxyphenyl)methanimine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 37/38-41-43
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=NC2=CC=C(C=C2)OC

Technology Process of N-(4-Methoxybenzylidene)-4-methoxyaniline

There total 40 articles about N-(4-Methoxybenzylidene)-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-benzaldehyde (123-11-5) + 4-methoxy-aniline (104-94-9) → N-(4-methoxy benzylidene)-4-methoxyaniline (1749-08-2)

Guidance literature:

In ethanol; for 1h; Sonication;

DOI:10.1016/j.ejmech.2021.113418

Reference yield: 99.0%

4-methoxy-benzaldehyde (123-11-5) + 4-methoxy-aniline (104-94-9) → (E)-1,N-bis(4-methoxyphenyl)methanimine (1624-46-0,1749-08-2,83306-67-6)

Guidance literature:

In methanol; at 20 ℃; for 0.166667h;

DOI:10.1246/bcsj.79.1941

Reference yield: 97.0%

4-methoxy-aniline (104-94-9) + 4-Methoxybenzyl alcohol (105-13-5) → N-(4-methoxy benzylidene)-4-methoxyaniline (1749-08-2)

Guidance literature:

With Mg-Al hydrotalcite doped with Fe(3+). Elemental composition: Mg - 29.4%, Al - 3.05%, Fe - 11.4%.; In 5,5-dimethyl-1,3-cyclohexadiene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c5gc00312a

upstream raw materials:

4-methoxy-benzaldehyde

4-methoxy-aniline

4'-chloro-4-methoxy-chalcone

N-(4-methoxybenzyl)-4-methoxyaniline

Downstream raw materials:

N-(4-methoxybenzyl)-4-methoxyaniline

2,3-bis-(4-methoxy-phenyl)-6-trichloromethyl-2,3-dihydro-[1,3,5]oxadiazin-4-one

1,4-bis(4-methoxyphenyl)-3-vinylazetidin-2-one

Refernces

• 1、 Mani, Timmy,Liu, Degang,Zhou, Donghui,Li, Liwei,Knabe, William Eric,Wang, Fang,Oh, Kyungsoo,Meroueh, Samy O.. "Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor". . p. 1963 - 1977. Retrieved 2013.
• 2、 Romero, Eugénie,Oueslati, Saoussen,Benchekroun, Mohamed,D'Hollander, Agathe C.A.,Ventre, Sandrine,Vijayakumar, Kamsana,Minard, Corinne,Exilie, Cynthia,Tlili, Linda,Retailleau, Pascal,Zavala, Agustin,Elisée, Eddy,Selwa, Edithe,Nguyen, Laetitia A.,Pruvost, Alain,Naas, Thierry,Iorga, Bogdan I.,Dodd, Robert H.,Cariou, Kevin. "Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D)". supporting information. . Retrieved 2021/04/19.
• 3、 Bari, Shamsher S.,Nagpal, Reshma,Pandey, Suvidha,Thakur, Aarti,Thapar, Renu. "A highly stereoselective oxidation and an easy one pot elimination methodology for 3-allyl-3-phenylthio-β-lactams". . . Retrieved 2021/12/24.