2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate

Base Information

Chemical Name:2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate
CAS No.:899427-37-3
Molecular Formula:C₂₃H₃₂INO₃Si
Molecular Weight:525.502
Hs Code.:

Synonyms:2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate

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Chemical Property of 2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate

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Technology Process of 2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate

There total 6 articles about 2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 899427-35-1
2-(tert-butyldimethylsilyloxy)phenylmethyl-6-(trimethylsilyl)phenyl isopropylcarbamate

: 899427-37-3
2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate

Guidance literature:: With potassium acetate; Iodine monochloride; In dichloromethane; at 0 - 20 ℃; for 12.5h;
DOI:10.1055/s-2006-926462

Reference yield:

: C₁₉H₃₅NO₂Si₂

: 899427-37-3
2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sec-butyllithium; TMEDA / diethyl ether; pentane / 1 h / -78 °C

1.2: diethyl ether; pentane / 1 h / -78 °C

2.1: 0.470 g / aq. HCl / methanol / -78 - 20 °C

3.1: 83 percent / DIPEA / CH₂Cl₂ / 2 h / 0 - 20 °C

4.1: 87 percent / ICl; KOAc / CH₂Cl₂ / 12.5 h / 0 - 20 °C

With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; potassium acetate; Iodine monochloride; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; pentane;
DOI:10.1055/s-2006-926462

Reference yield:

: 899427-31-7
2-hydroxyphenylmethyl-6-(trimethylsilyl)phenyl isopropylcarbamate

: 899427-37-3
2-(tert-butyldimethylsilyloxy)phenylmethyl-6-iodophenyl isopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / DIPEA / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 87 percent / ICl; KOAc / CH₂Cl₂ / 12.5 h / 0 - 20 °C

With potassium acetate; Iodine monochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1055/s-2006-926462