Technology Process of O-2-trimethylsilylphenyl N-isopropylcarbamate
There total 3 articles about O-2-trimethylsilylphenyl N-isopropylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenyl N-isopropylcarbamate;
With
N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate;
In
diethyl ether; pentane;
at 0 - 20 ℃;
for 0.583333h;
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
diethyl ether; pentane;
at -78 ℃;
for 1h;
chloro-trimethyl-silane;
In
diethyl ether; pentane;
at -78 ℃;
for 1h;
DOI:10.1139/v01-146
- Guidance literature:
-
C16H27NO2Si;
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
diethyl ether; hexane; pentane;
at -78 ℃;
Inert atmosphere;
chloro-trimethyl-silane;
In
diethyl ether; hexane; pentane;
at -78 ℃;
for 2h;
Inert atmosphere;
With
sodium hydrogen sulfate;
In
diethyl ether; hexane; water; pentane;
at -78 - 23 ℃;
for 0.75h;
DOI:10.1021/jo9020166
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 94 percent / DMAP / tetrahydrofuran / 24 h / 60 °C
2.1: N,N,N',N'-tetramethylethylenediamine; TMSOTf / diethyl ether; pentane / 0.58 h / 0 - 20 °C
2.2: N,N,N',N'-tetramethylethylenediamine; n-BuLi / diethyl ether; pentane / 1 h / -78 °C
2.3: 82 percent / diethyl ether; pentane / 1 h / -78 °C
With
dmap; N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate;
In
tetrahydrofuran; diethyl ether; pentane;
DOI:10.1139/v01-146
