(3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione

Base Information

Chemical Name:(3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione
CAS No.:736151-90-9
Molecular Formula:C₂₁H₂₃N₃O₅
Molecular Weight:397.431
Hs Code.:

Synonyms:(3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione

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Chemical Property of (3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione

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Technology Process of (3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione

There total 11 articles about (3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 736152-00-4
tert-butyl (4S,5S,1'R)-5-(2'-N-(4-methoxybenzyl)amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

: 736151-90-9
(3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione

Guidance literature:: tert-butyl (4S,5S,1'R)-5-(2'-N-(4-methoxybenzyl)amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate; With formic acid; at 60 ℃; for 8h;

With diphenyl-phosphinic acid; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1021/ol049215u

Reference yield: 61.0%

: 736152-02-6
tert-butyl (4S,5S,1'R)-5-(2'-N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate

: 736151-90-9
(3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione

Guidance literature:: tert-butyl (4S,5S,1'R)-5-(2'-N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)amino-1'-hydroxyethyl)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4-carboxylate; With formic acid; at 60 ℃;

With diphenyl-phosphinic acid; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1021/ol049215u

Reference yield:

: 736151-93-2
4-tert-butyl 5-ethyl (4S,5S)-1-(4-methoxyphenyl)-2-oxoimidazolidine-4,5-dicarboxylate

: 736151-90-9
(3aS,7R,7aS)-7-Hydroxy-5-(4-methoxy-benzyl)-1-(4-methoxy-phenyl)-hexahydro-imidazo[4,5-c]pyridine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: DIBAL-H / CH₂Cl₂; diethyl ether; toluene / 1 h / -78 °C

1.2: 32 percent / CH₂Cl₂; diethyl ether; toluene / 7 h / -78 - 0 °C

2.1: AcOH; H₂ / PtO₂ / 2 h / 20 °C

3.1: Na₂SO₄ / CH₂Cl₂ / 8 h / 20 °C

3.2: 71 percent / NaBH₄ / ethanol / 1 h / 0 °C

4.1: formic acid / 8 h / 60 °C

4.2: 65 percent / DPPA; Et₃N / dimethylformamide / 20 h / 20 °C

With formic acid; hydrogen; diisobutylaluminium hydride; acetic acid; sodium sulfate; platinum(IV) oxide; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol049215u