(+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine

Base Information

• Chemical Name: (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine
• CAS No.: 134619-79-7
• Molecular Formula: C₂₂H₂₆F₃NO₃
• Molecular Weight: 409.449
• Mol file: 134619-79-7.mol

Synonyms:(+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine

Chemical Property of (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine

There total 5 articles about (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-hydroxybenzotrifluoride (402-45-9) + (-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine (134619-77-5) → (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine (134619-79-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In diethyl ether; at -10 ℃; for 5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine (134619-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / CH₂Cl₂ / 2 h / Heating

2: 88 percent / PPh₃, diethyl azodicarboxylate / diethyl ether / 5 h / -10 °C

With triphenylphosphine; diethylazodicarboxylate; In diethyl ether; dichloromethane;

Reference yield:

(S)-N-methyl-3-amino-1-phenyl-1-propanol (114133-37-8) → (+)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propanamine (134619-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / CH₂Cl₂ / 2 h / Heating

2: 88 percent / PPh₃, diethyl azodicarboxylate / diethyl ether / 5 h / -10 °C

With triphenylphosphine; diethylazodicarboxylate; In diethyl ether; dichloromethane;

upstream raw materials:

4-hydroxybenzotrifluoride

(-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-hydroxypropylamine

di-tert-butyl dicarbonate

(S)-N-methyl-3-amino-1-phenyl-1-propanol

Downstream raw materials:

(R)-fluoxetine hydrochloride