134619-77-5Relevant academic research and scientific papers
HYDROXY ALIPHATIC SUBSTITUTED PHENYL AMINOALKYL ETHER DERIVATIVES
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, (2015/12/24)
New hydroxy aliphatic substituted phenyl aminoalkyl ether compounds of formula (I), compositions thereof and their use as a medicament in the treatment of nervous system diseases and/or the treatment of developmental, behavioral and/or mental disorders associated with cognitive deficits.
A novel chemoenzymatic enantioselective synthesis of some clinically effective CNS drugs and related compounds
Kumar, Ashok,Ner, D H,Dike, Suneel
, p. 803 - 809 (2007/10/02)
We have demonstrated in this study a novel route for the synthesis of benzothiopyran and benzothiazepin ring systems along with the synthesis of optically pure, clinically effective drugs tomoxetine, fluoxetine and thiazesim.
A new chemoenzymatic enantioselective synthesis of R-(-)-tomoxetine, (R)- and (S)-fluoxetine
Kumar, Ashok,Ner, Dilip H.,Dike, Suneel Y.
, p. 1901 - 1904 (2007/10/02)
A new chemoenzymatic synthesis of optically pure (R)-Tomoxetine and both the enantiomers of Fluoxetine starting from (S)-ethyl-3-hydroxy-3-phenyl propionate obtained by enzymatic methods, is described.
