N⁽⁶⁾-benzoyl-8-(bromomethyl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine

Base Information

• Chemical Name: N⁽⁶⁾-benzoyl-8-(bromomethyl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine
• CAS No.: 1040239-08-4
• Molecular Formula: C₂₉H₄₀BrN₅O₅Si
• Molecular Weight: 646.657
• Mol file: 1040239-08-4.mol

Synonyms:N⁽⁶⁾-benzoyl-8-(bromomethyl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine

Chemical Property of N⁽⁶⁾-benzoyl-8-(bromomethyl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁽⁶⁾-benzoyl-8-(bromomethyl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine

There total 1 articles about N⁽⁶⁾-benzoyl-8-(bromomethyl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonic acid 6-benzoylamino-9-{(3aR,4R,6R,6aR)-6-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-8-ylmethyl ester (801316-91-6) → N(6)-benzoyl-8-(bromomethyl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine (1040239-08-4)

Guidance literature:

With lithium bromide; In dichloromethane; at 23 ℃; for 16h; Inert atmosphere;

DOI:10.1002/hlca.200890071

Reference yield: 75.0%

N(6)-benzoyl-8-(bromomethyl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine (1040239-08-4) + 5'-S-acetyl-2',3'-O-isopropylidene-6-{[(4-methoxyphenyl)diphenylmethoxy]methyl}uridine (1040238-93-4) → 5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine-8-methyl-(8'->5'-S)-2',3'-O-isopropylidene-6-{[(4-methoxyphenyl)diphenylmethoxy]methyl}-5'-thiouridine (1040239-45-9)

Guidance literature:

With sodium methylate; In methanol; at 23 ℃; for 14h;

DOI:10.1002/hlca.200890071

upstream raw materials:

Methanesulfonic acid 6-benzoylamino-9-{(3aR,4R,6R,6aR)-6-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-8-ylmethyl ester

Downstream raw materials:

5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine-8-methyl-(8'->5'-S)-2',3'-O-isopropylidene-6-{[(4-methoxyphenyl)diphenylmethoxy]methyl}-5'-thiouridine