4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide

Base Information

• Chemical Name: 4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide
• CAS No.: 1372163-86-4
• Molecular Formula: C₁₈H₂₆N₂O₆
• Molecular Weight: 366.414
• Mol file: 1372163-86-4.mol

Synonyms:4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide

Chemical Property of 4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide

There total 2 articles about 4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tetraethylene glycol (112-60-7) → 4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide (1372163-86-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; paraffin oil / 24.5 h / -20 - 20 °C

2: triethylamine / dichloromethane / 16 h / 20 °C

3: caesium carbonate / dichloromethane / 16 h / Reflux

4: hydrazine hydrate / ethanol / 10 h / Reflux

With sodium hydride; caesium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; paraffin oil;

DOI:10.1021/bc200645n

Reference yield:

toluene-4-sulfonic acid 2-{2-[2-(2-ethynyloxyethoxy)-ethoxy]-ethoxy}-ethyl ester (875770-32-4) → 4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide (1372163-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / dichloromethane / 16 h / Reflux

2: hydrazine hydrate / ethanol / 10 h / Reflux

With caesium carbonate; hydrazine hydrate; In ethanol; dichloromethane;

DOI:10.1021/bc200645n

Reference yield: 85.0%

4-(2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid hydrazide (1372163-86-4) + C27H29NO10*ClH → C45H53N3O15

Guidance literature:

With trifluoroacetic acid; In ethanol; at 20 ℃; for 24h;

DOI:10.1021/bc200645n

upstream raw materials:

toluene-4-sulfonic acid 2-{2-[2-(2-ethynyloxyethoxy)-ethoxy]-ethoxy}-ethyl ester

Tetraethylene glycol