tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate
• CAS No.: 1246948-59-3
• Molecular Formula: C₄₁H₅₀ClN₅O₇S₃
• Molecular Weight: 856.528

Synonyms:tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(5-{(4-aminobutyl)[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate (1246948-57-1) + 5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) → tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate (1246948-59-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm1007177

Reference yield: 96.0%

tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate (1246948-59-3) → 5-chloro-N-[4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)-butyl]-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide (1246994-23-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jm1007177

upstream raw materials:

tert-butyl 4-(5-{(4-aminobutyl)[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

5-(dimethylamino)naphth-1-ylsulfonyl chloride

Downstream raw materials:

5-chloro-N-[4-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)-butyl]-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide

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