Dansyl chloride

Base Information

Chemical Name:Dansyl chloride
CAS No.:605-65-2
Deprecated CAS:558479-38-2
Molecular Formula:C12H12ClNO2S
Molecular Weight:269.752
Hs Code.:29214980
European Community (EC) Number:210-092-6
NSC Number:83616
UNII:QMU9166TJ4
DSSTox Substance ID:DTXSID2060543
Nikkaji Number:J6.823C
Wikipedia:Dansyl_chloride
Wikidata:Q409512
Metabolomics Workbench ID:57962
Mol file:605-65-2.mol

Synonyms:5-(dimethylamino)naphthalene-1-sulfonylchloride;5-(N,N-dimethylamino)naphthalene-1-sulfonyl chloride;dansyl chloride;dansyl chloride, 3H-labeled;dansylchloride;DNS-Cl

Suppliers and Price of Dansyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Dansyl Chloride
250mg
$ 403.00

TRC
Dansyl chloride
25g
$ 485.00

TCI Chemical
Dansyl Chloride >98.0%(HPLC)(T)
5g
$ 172.00

TCI Chemical
Dansyl Chloride >98.0%(HPLC)(T)
1g
$ 60.00

TCI Chemical
Dansyl Chloride >98.0%(HPLC)(T)
25g
$ 483.00

SynQuest Laboratories
5-Dimethylaminonaphthalene-1-sulfonyl chloride 98%
25 g
$ 376.00

SynQuest Laboratories
5-Dimethylaminonaphthalene-1-sulfonyl chloride 98%
1 g
$ 40.00

SynQuest Laboratories
5-Dimethylaminonaphthalene-1-sulfonyl chloride 98%
5 g
$ 96.00

Soltec Ventures
5-Dimethylaminonapthalene-1-sulfonyl chloride
2gm
$ 82.80

Soltec Ventures
5-Dimethylaminonapthalene-1-sulfonyl chloride
10gm
$ 391.00

Total 90 raw suppliers

Chemical Property of Dansyl chloride

Chemical Property:

Appearance/Colour:yellow to orange-yellow crystalline powder
Vapor Pressure:1.04E-05mmHg at 25°C
Melting Point:70-73 °C(lit.)
Refractive Index:1.636
Boiling Point:371.3 °C at 760 mmHg
PKA:2.38±0.40(Predicted)
Flash Point:178.4 °C
PSA：45.76000
Density:1.361 g/cm³
LogP:3.91410
Storage Temp.:2-8°C
Sensitive.:Moisture Sensitive
Solubility.:acetone: 50 mg/mL
Water Solubility.:Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water.
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:269.0277275
Heavy Atom Count:17
Complexity:363

Purity/Quality:

99%, ^*data from raw suppliers

Dansyl Chloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C
Statements: 34
Safety Statements: 26-36/37/39-45-3

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Other Classes -> Naphthalenes
Canonical SMILES:CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)Cl
Uses Dansyl chloride or 5-Dimethylaminonaphthalene-1-sulfonyl chloride (CAS 605-65-2) is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide. Dansyl chloride is non-fluorescent until it reacts with amines. The resulting Dansyl amides have environmentally sensitive fluorescence quantum yields and emission maxima along with large Stokes shifts. This environment-sensitive fluorescence property has made Dansyl chloride an important tool for biophysical studies. Reagent for fluorescent labelling of amines, amino acids and proteins. A fluorogenic reagent for N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC. In fluorescent labelling, column chromatography, HPLC. Dansyl chloride is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.

Technology Process of Dansyl chloride

There total 4 articles about Dansyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4272-77-9
dansyl acid

: 605-65-2
5-(dimethylamino)naphth-1-ylsulfonyl chloride

Guidance literature:: With phosphorus pentachloride; for 2h;

Reference yield: 73.0%

: 605-65-2
5-(dimethylamino)naphth-1-ylsulfonyl chloride

Guidance literature:

Reference yield:

: 84-89-9
1-aminonaphthalene-5-sulfonic acid

: 605-65-2
5-(dimethylamino)naphth-1-ylsulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NaHCO₃ / H₂O / 0.5 h / 80 °C

2: 75 percent / PCl₃ / 2 h / 60 °C

With sodium hydrogencarbonate; phosphorus trichloride; In water;
DOI:10.1002/hlca.19940770123