2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Base Information

Chemical Name:2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine
CAS No.:934472-07-8
Molecular Formula:C₁₇H₂₉NO₃SSi
Molecular Weight:355.574
Hs Code.:

2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Synonyms:2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

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Chemical Property of 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Chemical Property:

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Technology Process of 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

There total 3 articles about 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934472-06-7
2-hydroxyethyl-1-(toluene-4-sulfonyl)aziridine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 934472-07-8
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 0 - 20 ℃; for 8h;
DOI:10.1016/j.tetlet.2007.01.082

Reference yield:

: 147136-78-5
N-(3-hydroxy-1-hydroxymethyl-propyl)-4-methylbenzenesulfonamide

: 934472-07-8
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-(azodicarbonyl)dipiperidine; n-Bu₃P / toluene / 16 h / 0 - 20 °C

2: imidazole / tetrahydrofuran / 8 h / 0 - 20 °C

With 1H-imidazole; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; toluene; 1: Mitsunobu condensation;
DOI:10.1016/j.tetlet.2007.01.082

Reference yield:

: 95331-51-4
N-[(4-methylphenyl)sulfonyl]-L-aspartic acid 1,4-dimethyl ester

: 934472-07-8
2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / LiAlH₄ / tetrahydrofuran / 12 h / 0 - 20 °C

2: 1,1'-(azodicarbonyl)dipiperidine; n-Bu₃P / toluene / 16 h / 0 - 20 °C

3: imidazole / tetrahydrofuran / 8 h / 0 - 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; toluene; 2: Mitsunobu condensation;
DOI:10.1016/j.tetlet.2007.01.082