4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone

Base Information

• Chemical Name: 4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone
• CAS No.: 155432-51-2
• Molecular Formula: C₂₀H₁₇F₃N₆O₂
• Molecular Weight: 430.389

Synonyms:4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone

Chemical Property of 4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone

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Technology Process of 4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone

There total 2 articles about 4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1,2,4-Triazole (288-88-0) + 4-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl>-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone (155431-43-9) → 1-[(4R,5R)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-(2E)-ylidene]-3-(4-fluoro-phenyl)-urea + 4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone (155432-51-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 5h;

DOI:10.1248/cpb.44.314

Reference yield:

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole (124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2) + 1-(4-fluorophenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one (155431-42-8) + 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone (155432-46-5) → 4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone (155432-51-2)

Guidance literature:

Reference yield: 51.0%

4-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone (155432-51-2) → 1-[(4R,5R)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-(2E)-ylidene]-3-(4-fluoro-phenyl)-urea

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1248/cpb.44.314

upstream raw materials:

1,2,4-Triazole

4-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl>-2-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

1-(4-fluorophenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one

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