2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

Base Information

Chemical Name:2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone
CAS No.:155432-46-5
Molecular Formula:C₂₁H₁₇F₅N₆O₂
Molecular Weight:480.397
Hs Code.:

Synonyms:2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

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Chemical Property of 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

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Technology Process of 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

There total 5 articles about 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 288-88-0
1,2,4-Triazole

: 155431-31-5
2-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

: 155432-46-5
2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 5h;
DOI:10.1248/cpb.44.314

Reference yield:

: 126918-35-2
(1R)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

: 155432-46-5
2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h

2: 93 percent / NaOMe / methanol / 6 h

3: iso-Pr₂NEt / CH₂Cl₂ / 1.) -78 deg C, 20 min, 2.) -20 deg C, 20 min

4: NaH / CH₂Cl₂; dimethylformamide / 0.5 h / -10 - 0 °C

5: 42 percent / NaH / dimethylformamide / 5 h / 50 °C

With sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.314

Reference yield:

: 150802-97-4
[(1R)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] 3,5-dinitrobenzoate

: 155432-46-5
2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / 1 N aq. NaOH / methanol / 1 h / Ambient temperature

2: 78 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h

3: 93 percent / NaOMe / methanol / 6 h

4: iso-Pr₂NEt / CH₂Cl₂ / 1.) -78 deg C, 20 min, 2.) -20 deg C, 20 min

5: NaH / CH₂Cl₂; dimethylformamide / 0.5 h / -10 - 0 °C

6: 42 percent / NaH / dimethylformamide / 5 h / 50 °C

With sodium hydroxide; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.314