2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline

Base Information

Chemical Name:2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline
CAS No.:1613149-52-2
Molecular Formula:C₄₃H₃₃N₅
Molecular Weight:619.769
Hs Code.:

Synonyms:2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline

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Chemical Property of 2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline

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Technology Process of 2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline

There total 9 articles about 2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.6%

: 1146340-38-6
1-phenyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]-1H-benzo[d]imidazole

: 1613149-61-3
N-(4-(5-bromopyrazin-2-yl)phenyl)-2-methyl-N-(o-tolyl)aniline

: 1613149-52-2
2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

Reference yield:

: 359427-13-7
4-bromo-N-(2-(phenylamino)phenyl)benzamide

: 1613149-52-2
2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 1,4-dioxane / 100 °C

2: potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium carbonate; trichlorophosphate; In 1,4-dioxane; water;

Reference yield:

: 95-46-5
2-methylphenyl bromide

: 1613149-52-2
2-methyl-N-(4-(5-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)pyrazin-2-yl)phenyl)-N-(o-tolyl)aniline

Guidance literature:: Multi-step reaction with 6 steps

1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium t-butanolate / toluene / 100 °C / Neutral conditions

2: sodium t-butanolate; palladium diacetate; tri-tert-butyl phosphine / toluene / 40 h / 120 °C / Inert atmosphere

3: N-Bromosuccinimide / dichloromethane / 3 h / 0 °C

4: potassium acetate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / 1,4-dioxane / 100 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 90 °C / Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; tri-tert-butyl phosphine; potassium acetate; palladium diacetate; potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; In 1,4-dioxane; dichloromethane; water; toluene;