7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Base Information

Chemical Name:7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
CAS No.:1217299-23-4
Molecular Formula:C₁₄H₁₃FN₄O₂
Molecular Weight:288.281
Hs Code.:

Synonyms:7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

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Chemical Property of 7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

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Technology Process of 7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

There total 6 articles about 7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1217299-21-2
7-(4-amino-3-fluorophenoxy)-3-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

: 1217299-23-4
7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Guidance literature:: 7-(4-amino-3-fluorophenoxy)-3-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h; Inert atmosphere;

With methyl iodide; In tetrahydrofuran; for 1h;

Reference yield: 48.4%

: 1217299-21-2
7-(4-amino-3-fluorophenoxy)-3-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

: 74-88-4
methyl iodide

: 1217299-23-4
7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Guidance literature:: 7-(4-amino-3-fluorophenoxy)-3-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm900607f

Reference yield:

: 911297-02-4
N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

: 1217299-23-4
7-(4-amino-3-fluorophenoxy)-1,3-dimethyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 2 h / 50 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / H-Cube apparatus

3.1: pyridine / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux; Inert atmosphere

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

5.2: 1 h

With pyridine; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide; mineral oil;