N-(2-Chloro-2-phenylethyl)-N-(diphenylmethyl)glycine 1,1-dimethylethyl ester

Base Information

Chemical Name:N-(2-Chloro-2-phenylethyl)-N-(diphenylmethyl)glycine 1,1-dimethylethyl ester
CAS No.:158980-49-5
Molecular Formula:C₂₇H₃₀ClNO₂
Molecular Weight:435.994
Hs Code.:
DSSTox Substance ID:DTXSID401141229

Synonyms:DTXSID401141229;N-(2-Chloro-2-phenylethyl)-N-(diphenylmethyl)glycine 1,1-dimethylethyl ester;158980-49-5

Suppliers and Price of N-(2-Chloro-2-phenylethyl)-N-(diphenylmethyl)glycine 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of N-(2-Chloro-2-phenylethyl)-N-(diphenylmethyl)glycine 1,1-dimethylethyl ester

Chemical Property:

XLogP3:6.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:10
Exact Mass:435.1965069
Heavy Atom Count:31
Complexity:510

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CN(CC(C1=CC=CC=C1)Cl)C(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of N-(2-Chloro-2-phenylethyl)-N-(diphenylmethyl)glycine 1,1-dimethylethyl ester

There total 6 articles about N-(2-Chloro-2-phenylethyl)-N-(diphenylmethyl)glycine 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 158980-48-4
N-(Diphenylmethyl)-N-(2-hydroxy-2-phenylethyl)glycine 1,1-dimethylethyl ester

: 158980-49-5
N-(Diphenylmethyl)-N-(2-chloro-2-phenylethyl)glycine 1,1-dimethylethyl ester

Guidance literature:: With thionyl chloride; In chloroform; for 0.5h; Yield given;
DOI:10.1021/jo00099a050

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 158980-49-5
N-(Diphenylmethyl)-N-(2-chloro-2-phenylethyl)glycine 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / K₂CO₃, KI / dimethylformamide / 2 h

2: 95 percent / N,N-diisopropylethylamine / acetone / Heating

3: NaBH₄, CeCl₃*7H₂O / methanol; tetrahydrofuran / 0.17 h / -23 °C

4: SOCl₂ / CHCl₃ / 0.5 h

With sodium tetrahydroborate; thionyl chloride; cerium(III) chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00099a050

Reference yield:

: 70-11-1
α-bromoacetophenone

: 158980-49-5
N-(Diphenylmethyl)-N-(2-chloro-2-phenylethyl)glycine 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / N,N-diisopropylethylamine / acetone / Heating

2: NaBH₄, CeCl₃*7H₂O / methanol; tetrahydrofuran / 0.17 h / -23 °C

3: SOCl₂ / CHCl₃ / 0.5 h

With sodium tetrahydroborate; thionyl chloride; cerium(III) chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; chloroform; acetone;
DOI:10.1021/jo00099a050