[1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester

Base Information

• Chemical Name: [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester
• CAS No.: 83567-78-6
• Molecular Formula: C₁₂H₁₆F₂NO₆P
• Molecular Weight: 339.233
• Mol file: 83567-78-6.mol

Synonyms:[1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester

Chemical Property of [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester

There total 4 articles about [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-nitrobenzaldehdye (555-16-8) + diethyl difluoro(trimethylsilyl)methylphosphonate (80077-72-1) → [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester (83567-78-6)

Guidance literature:

4-nitrobenzaldehdye; diethyl difluoro(trimethylsilyl)methylphosphonate; With copper diacetate; 1,2-bis-(diphenylphosphino)ethane; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1039/b603041f

Reference yield: 14.0%

4-nitrobenzaldehdye (555-16-8) + diethyl difluoromethylphosphonate lithium salt (94993-99-4,83567-74-2) → [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester (83567-78-6) + Phosphoric acid 2,2-difluoro-1-(4-nitro-phenyl)-ethyl ester diethyl ester (83567-82-2)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(00)87332-3

Reference yield:

[1,1-Difluoro-2-(4-nitro-phenyl)-2-trimethylsilanyloxy-ethyl]-phosphonic acid diethyl ester → [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester (83567-78-6)

Guidance literature:

With hydrogenchloride; Product distribution;

DOI:10.1016/S0040-4039(00)87333-5

upstream raw materials:

4-nitrobenzaldehdye

diethyl difluoromethylphosphonate lithium salt

diethyl difluoro(trimethylsilyl)methylphosphonate

Diethyl difluoromethylphosphonate

Downstream raw materials:

1-(2,2-difluorovinyl)-4-nitrobenzene

Phosphoric acid 2,2-difluoro-1-(4-nitro-phenyl)-ethyl ester diethyl ester