2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Base Information

Chemical Name:2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione
CAS No.:1197396-96-5
Molecular Formula:C₂₃H₂₅Cl₂N₅O₂
Molecular Weight:474.39
Hs Code.:

Synonyms:2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

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Chemical Property of 2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

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Technology Process of 2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

There total 11 articles about 2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1075238-48-0
2-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

: 81156-65-2
2-(3,4-dichlorophenyl)ethyl methanesulfonate

: 1197396-96-5
2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Guidance literature:: 2-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione; 2-(3,4-dichlorophenyl)ethyl methanesulfonate; With potassium carbonate; In acetonitrile; at 60 ℃; Reflux;

sodium iodide; In acetonitrile; at 20 ℃;

Reference yield:

: 757186-96-2
2-{[6-(methyloxy)-3-nitro-2-pyridinyl]amino}-1,3-propanediol

: 1197396-96-5
2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene-4-sulfonic acid / 20 °C / Inert atmosphere

1.2: 0.33 h

2.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; water / 18 h / 20 °C / 760.05 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 0 - 20 °C

5.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

6.2: pH ~ 8

7.1: triethylamine / chloroform / 4.5 h / Reflux; Inert atmosphere

8.1: pyridine / acetonitrile / 50 - 90 °C / Reflux; Inert atmosphere

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

10.1: ammonia / methanol; water

11.1: potassium carbonate / acetonitrile / 60 °C / Reflux

11.2: 20 °C

With pyridine; hydrogenchloride; manganese(IV) oxide; ammonia; water; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 1197396-96-5
2-[(4-{[2-(3,4-dichlorophenyl)ethyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Guidance literature:: Multi-step reaction with 12 steps

1.1: ethanol / 3 h / Inert atmosphere; Reflux

2.1: toluene-4-sulfonic acid / 20 °C / Inert atmosphere

2.2: 0.33 h

3.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; water / 18 h / 20 °C / 760.05 Torr

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

5.2: 0 - 20 °C

6.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C

7.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

7.2: pH ~ 8

8.1: triethylamine / chloroform / 4.5 h / Reflux; Inert atmosphere

9.1: pyridine / acetonitrile / 50 - 90 °C / Reflux; Inert atmosphere

10.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

11.1: ammonia / methanol; water

12.1: potassium carbonate / acetonitrile / 60 °C / Reflux

12.2: 20 °C

With pyridine; hydrogenchloride; manganese(IV) oxide; ammonia; water; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;