tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Base Information

Chemical Name:tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate
CAS No.:1446266-81-4
Molecular Formula:C₃₉H₄₆N₄O₈
Molecular Weight:698.816
Hs Code.:

tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Synonyms:tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

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Chemical Property of tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

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Technology Process of tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

There total 5 articles about tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1446266-79-0
tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

: 929-06-6
2-(2-Aminoethoxy)ethanol

: 1446266-81-4
tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1446266-77-8
tert-butyl [7-{[1-(4-hydroxyphenyl)-2-methylindolizin-3-yl]carbonyl}-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]acetate

: 1446266-81-4
tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / -5 °C

1.2: 3 h / -5 °C

2.1: potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With sodium hydride; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1446266-81-4
tert-butyl {7-[(1-{4-[(5-{[2-(2-hydroxyethoxy)ethyl]amino}pentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; aq. phosphate buffer / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / -5 °C

2.2: 3 h / -5 °C

3.1: potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; potassium iodide; In aq. phosphate buffer; N,N-dimethyl-formamide; mineral oil;