tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

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Chemical Name:tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate
CAS No.:1446266-79-0
Molecular Formula:C₃₅H₃₆IN₃O₆
Molecular Weight:721.592
Hs Code.:

Synonyms:tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

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Chemical Property of tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

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Technology Process of tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

There total 4 articles about tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1446266-78-9
tert-butyl {7-[(1-{4-[(5-chloropentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

: 1446266-79-0
tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: With potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield:

: 1446266-77-8
tert-butyl [7-{[1-(4-hydroxyphenyl)-2-methylindolizin-3-yl]carbonyl}-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]acetate

: 1446266-79-0
tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / -5 °C

1.2: 3 h / -5 °C

2.1: potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C

With sodium hydride; potassium iodide; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1446266-79-0
tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; aq. phosphate buffer / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / -5 °C

2.2: 3 h / -5 °C

3.1: potassium iodide / N,N-dimethyl-formamide / 6 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium iodide; In aq. phosphate buffer; N,N-dimethyl-formamide; mineral oil;