(5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

Base Information

Chemical Name:(5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one
CAS No.:348626-50-6
Molecular Formula:C₁₄H₁₇N₃O₃
Molecular Weight:275.307
Hs Code.:

Synonyms:(5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

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Chemical Property of (5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

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Technology Process of (5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

There total 4 articles about (5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348626-49-3
(5R)-5-(hydroxymethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

: 1074-82-4
potassium phtalimide

: 124-63-0
methanesulfonyl chloride

: 348626-50-6
(5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

Guidance literature:: With sodium hydrogencarbonate; hydrazine hydrate; triethylamine; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 348626-49-3
(5R)-5-(hydroxymethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

: 348626-50-6
(5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

Guidance literature:: (5R)-5-(hydroxymethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4.5h;

With potassium phtalimide; In acetonitrile; at 180 ℃; for 0.75h; microwave irradiation;

With hydrazine hydrate; In methanol; for 2h; Heating;
DOI:10.1021/jm050101d

Reference yield:

: 348626-48-2
benzyl [4-(2-oxopyrrolidin-1-yl)phenyl]carbamate

: 348626-50-6
(5S)-5-(aminomethyl)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; isoamyl alcohol / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 90 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: MeSO₂Cl; Et₃N / CH₂Cl₂ / 4.5 h / 0 - 20 °C

2.2: potassium phthalimide / acetonitrile / 0.75 h / 180 °C / microwave irradiation

2.3: hydrazine hydrate / methanol / 2 h / Heating

With n-butyllithium; i-Amyl alcohol; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm050101d