(E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

Base Information

Chemical Name:(E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol
CAS No.:1394837-85-4
Molecular Formula:C₁₈H₁₈Cl₂O₄
Molecular Weight:369.245
Hs Code.:

Synonyms:(E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

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Chemical Property of (E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

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Technology Process of (E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

There total 10 articles about (E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: C₂₄H₃₀Cl₂O₄

: 1394837-85-4
(E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

Guidance literature:: With boron trichloride; In dichloromethane; at -78 - 23 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2020.151856

Reference yield:

: C₂₈H₃₄Cl₂O₆

: 1394837-85-4
(E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

: 1394837-86-5
(Z)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

Guidance literature:: With methanol; caesium carbonate; In dichloromethane; at 20 ℃; for 6h; optical yield given as %de;
DOI:10.3390/md10051103

Reference yield:

: 1394837-77-4
(4-chloro-2,5-dimethoxyphenyl)methanol

: 1394837-85-4
(E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide / dichloromethane; water / 0 - 20 °C

2.1: palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 0.1 h / 20 °C / Inert atmosphere

2.3: 0.07 h / 120 °C / Microwave irradiation

3.1: methanol; caesium carbonate / dichloromethane / 6 h / 20 °C

With methanol; hydrogen bromide; palladium diacetate; caesium carbonate; tris-(o-tolyl)phosphine; In dichloromethane; water; N,N-dimethyl-formamide; 2.3: Negishi coupling reaction;
DOI:10.3390/md10051103