(E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol

Base Information

Chemical Name:(E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol
CAS No.:1394837-87-6
Molecular Formula:C₁₆H₁₄Cl₂O₄
Molecular Weight:341.191
Hs Code.:

Synonyms:(E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol

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Technology Process of (E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol

There total 7 articles about (E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1394837-85-4
(E)-5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

: 1394837-87-6
(E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃;
DOI:10.3390/md10051103

Reference yield:

: 5-(2-chloro-4-(4-chloro-2,5-dimethoxyphenyl)but-2-enyl)benzene-1,3-diol

: 1394837-87-6
(E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol

: (E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; optical yield given as %de;
DOI:10.3390/md10051103

Reference yield:

: 1394837-77-4
(4-chloro-2,5-dimethoxyphenyl)methanol

: 1394837-87-6
(E)-5-(2-chloro-4-(4-chloro-2,5-dihydroxyphenyl)but-2-enyl)benzene-1,3-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide / dichloromethane; water / 0 - 20 °C

2.1: palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 0.1 h / 20 °C / Inert atmosphere

2.3: 0.07 h / 120 °C / Microwave irradiation

3.1: methanol; caesium carbonate / dichloromethane / 6 h / 20 °C

4.1: boron tribromide / dichloromethane / 0 - 20 °C

With methanol; hydrogen bromide; palladium diacetate; boron tribromide; caesium carbonate; tris-(o-tolyl)phosphine; In dichloromethane; water; N,N-dimethyl-formamide; 2.3: Negishi coupling reaction;
DOI:10.3390/md10051103