(S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide

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Chemical Name:(S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide
CAS No.:1370705-63-7
Molecular Formula:C₂₃H₂₄FN₇O₅S
Molecular Weight:529.552
Hs Code.:

Synonyms:(S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide

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Chemical Property of (S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide

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Technology Process of (S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide

There total 7 articles about (S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.8%

: 1370705-54-6
3-(azidomethyl)-4-phenyl-1,2,5-oxadiazole-2-oxide

: 1370705-96-6
(S)-2-(4-fluorophenylsulfonamido)-3-methyl-N-(prop-2-ynyl)butanamide

: 1370705-63-7
(S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm201504s

Reference yield:

: 97801-48-4
(S)-2-(4-fluorobenzenesulfonylamino)-3-methylbutanoic acid

: 1370705-63-7
(S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / toluene / 20 °C / Inert atmosphere

With copper(l) iodide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm201504s

Reference yield:

: C₁₆H₁₄N₂O₅S

: 1370705-63-7
(S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / Heating; Inert atmosphere

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / toluene / 20 °C / Inert atmosphere

With copper(l) iodide; sodium azide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm201504s