1370705-54-6

Basic information

• Product Name: 3-(azidomethyl)-4-phenyl-1,2,5-oxadiazole-2-oxide
• Synonyms: 3-(azidomethyl)-4-phenyl-1,2,5-oxadiazole-2-oxide
• CAS NO: 1370705-54-6
• Molecular Weight: 217.187
• Mol File: 1370705-54-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(azidomethyl)-4-phenyl-1,2,5-oxadiazole-2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(azidomethyl)-4-phenyl-1,2,5-oxadiazole-2-oxide(1370705-54-6)
• EPA Substance Registry System: 3-(azidomethyl)-4-phenyl-1,2,5-oxadiazole-2-oxide(1370705-54-6)

Safety Data

• Hazardous Substances Data: 1370705-54-6(Hazardous Substances Data)

Upstream product

• 169614-78-2 3-(bromomethyl)-2-oxido-4-phenyl-1,2,5-oxadiazole 
• 6898-86-8 3-methyl-4-phenylfuroxan 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 
• 104-54-1 3-Phenylpropenol 

Downstream Products

• 1370705-63-7 (S)-3-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide 
• 1370705-70-6 (S)-4-((4-((2-(4-fluorophenylsulfonamido)-3-methylbutanamido)methyl)-1H-1,2,3-triazol-1-yl)methyl)-3-phenyl-1,2,5-oxadiazole-2-oxide 
• 1370705-82-0 (S)-3-((4-methyl-2-(phenylsulfonamido)pentanamido)methyl)-4-phenyl-1,2,5-oxadiazole-2-oxide 
• 1370705-88-6 (R)-4-methyl-N-((4-phenyl-1,2,5-oxadiazol-3-yl)methyl)-2-(phenylsulfonamido)pentanamide 
• 169614-87-3 3-(aminomethyl)-4-phenyl-1,2,5-oxadiazole-2-oxide 
• 1370705-58-0 4-phenyl-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)-1,2,5-oxadiazole-2-oxide 

Relevant articles and documents

Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists

The P2X7 receptor is a promising target for the treatment of various diseases due to its significant role in inflammation and immune cell signaling. This work describes the design, synthesis, and in vitro evaluation of a series of novel derivatives bearing diverse scaffolds as potent P2X7 antagonists. Our approach was based on structural modifications of reported (adamantan-1-yl)methylbenzamides able to inhibit the receptor activation. The adamantane moieties and the amide bond were replaced, and the replacements were evaluated by a ligand-based pharmacophore model. The antagonistic potency of the synthesized analogues was assessed by two-electrode voltage clamp experiments, using Xenopus laevis oocytes that express the human P2X7 receptor. SAR studies suggested that the replacement of the adamantane ring by an aryl-cyclohexyl moiety afforded the most potent antagonists against the activation of the P2X7 cation channel, with analogue 2-chloro-N-[1-(3-(nitrooxymethyl)phenyl)cyclohexyl)methyl]benzamide (56) exhibiting the best potency with an IC50 value of 0.39 μΜ.

Furoxans (1,2,5-Oxadiazole- N -oxides) as novel no mimetic neuroprotective and procognitive agents

Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents adjacent to the furoxan ring system led to modulation of reactivity toward bioactivation, studied