2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

Base Information

Chemical Name:2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride
CAS No.:1609461-64-4
Molecular Formula:C₁₉H₁₇N₅O₂*ClH
Molecular Weight:383.837
Hs Code.:

Synonyms:2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

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Chemical Property of 2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

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Technology Process of 2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

There total 2 articles about 2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: tert-butyl 2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazole-1-carboxylate

: 1609461-64-4
2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; ethanol; at 20 ℃; for 5h;
DOI:10.1039/c4md00286e

Reference yield:

: 4382-54-1
5-methoxy-1H-indole-2-carboxylic acid

: 1574306-17-4
tert-butyl 2-amino-4-(3-aminophenyl)-1H-imidazole-1-carboxylate

: 1609461-64-4
2-amino-4-(3-(5-methoxy-1H-indole-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane

2: hydrogenchloride / tetrahydrofuran; ethanol / 5 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1039/c4md00286e