(E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

Base Information

• Chemical Name: (E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile
• CAS No.: 195433-99-9
• Molecular Formula: C₂₂H₂₅N₂O₃P
• Molecular Weight: 396.426

Synonyms:(E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

Chemical Property of (E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

There total 3 articles about (E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + (E)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ5-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile (195433-96-6) → (E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ5-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile (195433-99-9)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; In tetrahydrofuran; hexane; at -108 ℃; Yield given; 1.) 20 min, 2.) 4 h;

DOI:10.1021/jo970854a

Reference yield:

(E)-2-hydroxypent-3-enenitrile (193805-19-5) → (E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ5-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile (195433-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: n-BuLi, DMPU / tetrahydrofuran; hexane / -108 °C / 1.) 20 min, 2.) 4 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo970854a

Reference yield:

(4S)-2-chloro-3,4r-dimethyl-5t-phenyl-[1,3,2]oxazaphospholidine 2ξ-oxide (13897-77-3,28080-18-4,28080-19-5,31060-10-3,31060-12-5,53625-09-5,53625-11-9,54750-12-8,54750-13-9,72691-41-9,149116-52-9) → (E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ5-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile (195433-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: n-BuLi, DMPU / tetrahydrofuran; hexane / -108 °C / 1.) 20 min, 2.) 4 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo970854a

upstream raw materials:

benzyl bromide

(E)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

(E)-2-hydroxypent-3-enenitrile

(4S)-2-chloro-3,4r-dimethyl-5t-phenyl-[1,3,2]oxazaphospholidine 2ξ-oxide

Downstream raw materials:

(S)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pentanenitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 195433-99-9 (E)-(R)-2-Benzyl-2-((2S,4S,5S)-3,4-dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send