methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate

Base Information

Chemical Name:methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate
CAS No.:926297-55-4
Molecular Formula:C₂₀H₂₁ClF₃NO₆
Molecular Weight:463.838
Hs Code.:

Synonyms:methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate

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Chemical Property of methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate

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Technology Process of methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate

There total 6 articles about methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 926297-55-4
methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate

Guidance literature:: methyl 3-[2-hydroxy-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate; With sodium iodide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

2,3-dichloro-5-trifluoromethylpyridine; In N,N-dimethyl-formamide; at 0 - 30 ℃; for 0.5h;

Reference yield: 75.0%

: 926297-54-3
methyl 3-[2-hydroxy-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 926297-55-4
methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate

Guidance literature:: methyl 3-[2-hydroxy-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

2,3-dichloro-5-trifluoromethylpyridine; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 2-hydroxy-4-(2-methoxyethoxy)-benzaldehyde

: 926297-55-4
methyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 2 h / 0 °C

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.03.036