2,3-Dichloro-5-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2,3-Dichloro-5-(trifluoromethyl)pyridine
• CAS No.: 69045-84-7
• Molecular Formula: C6H2Cl2F3N
• Molecular Weight: 215.99
• Hs Code.: 29333990
• European Community (EC) Number: 410-340-5,614-913-2
• UNII: 5F2C8LX8IE
• DSSTox Substance ID: DTXSID7074080
• Nikkaji Number: J43.077C
• Wikidata: Q27261950
• Mol file: 69045-84-7.mol

Synonyms:2,3-Dichloro-5-(trifluoromethyl)pyridine;69045-84-7;2,3-Dichloro-5-trifluoromethylpyridine;2,3-dichloro-5-trifluoromethyl pyridine;69645-84-7;UNII-5F2C8LX8IE;5F2C8LX8IE;2,3-dichloro-5-trifluoromethyl-pyridine;Pyridine, 2,3-dichloro-5-(trifluoromethyl)-;2,3-dichloro-5-(trifluoromethyl)-pyridine;EC 410-340-5;2,3,5-dctf;2,3-Dichloro-5-trifluoro methylpyridine;MFCD00042243;SCHEMBL120994;DTXSID7074080;ABNQGNFVSFKJGI-UHFFFAOYSA-;AC-331;BBL004464;STK400198;AKOS000119166;2,3-dichioro-5-trifluoromethylpyridine;PB47841;2,3 dichloro-5-trifluoromethyl pyridine;2,3,-Dichloro-5-(trifluoromethyl)pyridine;2,3-di-chloro-5-(trifluoromethyl)pyridine;AM20070080;BB 0242387;CS-0015949;FT-0609539;EN300-19151;2,3-bis(chloranyl)-5-(trifluoromethyl)pyridine;2,3-Dichloro-5-(trifluoromethyl)pyridine, 97%;A836328;Q-101451;Q-101474;Q27261950;F0001-1796

Chemical Property of 2,3-Dichloro-5-(trifluoromethyl)pyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Vapor Pressure: 0.00017mmHg at 25°C
• Melting Point: 8-9 °C
• Refractive Index: n20/D 1.475(lit.)
• Boiling Point: 188.5 °C at 760 mmHg
• PKA: -3.34±0.10(Predicted)
• Flash Point: 79.4 °C
• PSA: 12.89000
• Density: 1.542 g/cm³
• LogP: 3.40720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 214.9516389
• Heavy Atom Count: 12
• Complexity: 161

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dichloro-5-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, N, Xi
• Hazard Codes: Xn,N,Xi
• Statements: 20/22-41-43-51/53-36/37/38
• Safety Statements: 24-26-37/39-61-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)Cl)C(F)(F)F

Technology Process of 2,3-Dichloro-5-(trifluoromethyl)pyridine

There total 20 articles about 2,3-Dichloro-5-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

2,3-dihydroxy-5-trifluoromethylpyridine → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Guidance literature:

With phosphorus pentachloride; In 1,2-dichloro-ethane; at 60 - 65 ℃; for 8h; Solvent; Temperature;

Reference yield: 97.7%

→ 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Guidance literature:

Reference yield: 96.0%

2,3-dichloro-5-(trichloromethyl)pyridine (69045-83-6) → 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7)

Guidance literature:

With Tetrafluorophthalonitrile; tetrabutyl ammonium fluoride; In acetonitrile; at 60 ℃; for 6h; Solvent; Temperature; Reagent/catalyst;

upstream raw materials:

2,3-dichloro-5-(trichloromethyl)pyridine

2,2-dichloro-3,3,3-trifluoro-propionaldehyde

acrylonitrile

antimony(III) fluoride

Downstream raw materials:

2-amino-3-chloro-5-(trifluoromethyl)pyridine

3-chloro-5-(trifluoromethyl)-2-hydroxypyridine

3-chloro-5-(trifluoromethyl)pyridine-2-thiol

3-chloro-5-(trifluoromethyl)-pyridin-2-yl-hydrazine

Refernces

• 1、 -. "Preparation method 2-3 - dichloro -5 - trifluoromethylpyridine". Paragraph 0024-0033. . Retrieved 2021/10/27.
• 2、 -. "METHOD FOR PREPARING 2,3-DICHLORO-5-TRIFLUOROMETHYLPYRIDINE WITH HIGH SELECTIVITY". Paragraph 0147-0149; 0151-0153; 0156-0157; 0159; 0161. . Retrieved 2020/04/24.