5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate

Base Information

Chemical Name:5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate
CAS No.:1388221-52-0
Molecular Formula:C₂₇H₂₀ClNO₅
Molecular Weight:473.912
Hs Code.:

Synonyms:5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate

Chemical Property:

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Technology Process of 5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate

There total 6 articles about 5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201816-71-8
5-(2-hydroxy-4-methoxybenzoyl)-1-o-tolylphenylpyridin-2(1H)-one

: 122-01-0
4-chloro-benzoyl chloride

: 1388221-52-0
5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2013.06.046

Reference yield:

: 552-41-0
1-(2-hydroxy-4-methoxyphenyl)ethanone

: 1388221-52-0
5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium / diethyl ether / 0 °C

2: acetic acid; hydrogenchloride / water / 0.5 h / 100 °C

3: methanol / Reflux

4: iodine / dichloromethane

5: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate / water; tetrahydrofuran / 100 °C

6: methanol / Reflux

7: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 5: |Heck Reaction;
DOI:10.1016/j.ejmech.2013.06.046

Reference yield:

: 94719-81-0
ω-formyl-4'-methoxy-2'-hydroxyacetophenone

: 1388221-52-0
5-methoxy-2-(6-oxo-1-o-tolyl-1,6-dihydropyridine-3-carbonyl)phenyl 4-chlorobenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; hydrogenchloride / water / 0.5 h / 100 °C

2: methanol / Reflux

3: iodine / dichloromethane

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate / water; tetrahydrofuran / 100 °C

5: methanol / Reflux

6: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; 4: |Heck Reaction;
DOI:10.1016/j.ejmech.2013.06.046