N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

Base Information

Chemical Name:N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide
CAS No.:1228465-68-6
Molecular Formula:C₂₄H₁₆Cl₂F₃N₅O₃S
Molecular Weight:582.39
Hs Code.:

Synonyms:N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

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Chemical Property of N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

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Technology Process of N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

There total 8 articles about N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1125632-75-8
N-[5-(3-amino-4-chlorophenoxy) [1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1228465-68-6
N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield:

: 16026-77-0
3-amino-4-chlorophenol

: 1228465-68-6
N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: tetrahydrofuran / 1 h / 20 °C

3: acetic acid; iron / 3 h / 60 °C

4: bromine; acetic acid / 16 h / 20 °C / Cooling with ice

5: pyridine / 1 h / 20 °C / Cooling with ice

6: ethanol; sodium tetrahydroborate; methanol / 1 h / 20 °C / Cooling

7: N,N-dimethyl-formamide / 10 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; ethanol; bromine; iron; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1228465-68-6
N-{5-[4-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: tetrahydrofuran / 1 h / 20 °C

3: acetic acid; iron / 3 h / 60 °C

4: bromine; acetic acid / 16 h / 20 °C / Cooling with ice

5: pyridine / 1 h / 20 °C / Cooling with ice

6: ethanol; sodium tetrahydroborate; methanol / 1 h / 20 °C / Cooling

7: N,N-dimethyl-formamide / 10 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; ethanol; bromine; iron; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;